PKMζ-PKC{iota}/{lambda} double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory
Panayiotis Tsokas, Changchi Hsieh, Alejandro Borja Grau-Perales, Andrew Tcherepanov, Leo Kwok, Laura Melissa Rodriguez-Valencia, David A. Cano, Kim Allen, Hannah J. H. Smith, Sabina Kubayeva, Benson J. Wei, Samuel Sabzanov, Rafael E. Flores‐Obando, Sourav Ghosh, Peter John Bergold, , Todd Charlton Sacktor
The paper shows that PKC{iota}/{lambda} compensates for PKM{zeta} in maintaining hippocampal late-LTP and spatial memory when PKM{zeta} is absent.
eLife · Jul 22, 2026Peer-reviewedNeuroscience