Todd Charlton Sacktor

PKMζ-PKC{iota}/{lambda} double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory

The paper shows that PKC{iota}/{lambda} compensates for PKM{zeta} in maintaining hippocampal late-LTP and spatial memory when PKM{zeta} is absent.

Persistently increased expression of PKMζ and unbiased gene expression profiles identify hippocampal molecular traces of a long-term active place avoidance memory and 'shadow' proteins

The paper identifies molecular traces of long-term memory using gene expression and protein analysis, revealing shadow proteins like PKMζ that are not detected by transcriptome profiling.

PKMζ-KIBRA interactions, molecular turnover, and memory

The paper investigates how KIBRA-PKMζ interactions sustain long-term memory despite molecular turnover by forming oligomers that continuously incorporate new molecules.

Maintenance of memory by negative-feedback of synaptic protein elimination: Modeling KIBRA-PKMζ dynamics in LTP.

The paper proposes a negative-feedback theory for memory maintenance through KIBRA-PKMζ interactions and validates it with two models showing bistability in synaptic states.

Increased protein kinase Mζ expression by Minocycline and N-acetylcysteine restoreslate-phase long-term potentiation and spatial learning after closed head injury in mice

MN12 treatment increases PKMζ expression, restoring LTP and spatial learning in mice with closed head injury.

Amygdala stimulation transforms short-term memory into remote memory by persistent activation of atypical PKC in the anterior cingulate cortex

The paper shows that amygdala stimulation after short-term memory can convert it into remote memory, with the effect mediated through the anterior cingulate cortex rather than the hippocampus.

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

This study shows that CT-KIBRA repairs synaptic plasticity and memory in tauopathy models by stabilizing PKMζ, without altering tau levels or preventing synapse loss.

Conditions for synaptic specificity during the maintenance phase of synaptic plasticity

This study investigates the conditions for synaptic specificity during memory maintenance by simulating protein dynamics in dendritic spines.

Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage

The paper shows that persistent PKMζ increases in specific hippocampal neurons during LTP maintenance and spatial memory storage, indicating its role in long-term memory.

Persistent increases of PKMζ in sensorimotor cortex maintain procedural long-term memory storage

This study shows that persistent increases in PKMζ in specific layers of the sensorimotor cortex are necessary for maintaining long-term procedural memories in rats.