Alejandro Borja Grau-Perales

PKMζ-PKC{iota}/{lambda} double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory

The paper shows that PKC{iota}/{lambda} compensates for PKM{zeta} in maintaining hippocampal late-LTP and spatial memory when PKM{zeta} is absent.

Persistently increased expression of PKMζ and unbiased gene expression profiles identify hippocampal molecular traces of a long-term active place avoidance memory and 'shadow' proteins

The paper identifies molecular traces of long-term memory using gene expression and protein analysis, revealing shadow proteins like PKMζ that are not detected by transcriptome profiling.

Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

This study shows that neuronal TIMP2 regulates hippocampus-dependent memory by controlling extracellular matrix accumulation and adult neurogenesis.

A Photoactivated Protein Degrader for Optical Control of Synaptic Function

This paper introduces PHOTACs, a method to optically degrade specific proteins in brain tissue, and demonstrates its effectiveness in reducing synaptic function in mice.

Learning to learn persistently modifies an entorhinal-hippocampal excitatory-inhibitory subcircuit

The paper shows that cognitive control training in mice leads to long-lasting changes in hippocampal circuitry that enhance signal-to-noise processing.

Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage

The paper shows that persistent PKMζ increases in specific hippocampal neurons during LTP maintenance and spatial memory storage, indicating its role in long-term memory.