Changchi Hsieh

The paper shows that PKC{iota}/{lambda} compensates for PKM{zeta} in maintaining hippocampal late-LTP and spatial memory when PKM{zeta} is absent.

The paper investigates how KIBRA-PKMζ interactions sustain long-term memory despite molecular turnover by forming oligomers that continuously incorporate new molecules.

The paper proposes a negative-feedback theory for memory maintenance through KIBRA-PKMζ interactions and validates it with two models showing bistability in synaptic states.

MN12 treatment increases PKMζ expression, restoring LTP and spatial learning in mice with closed head injury.

The paper shows that amygdala stimulation after short-term memory can convert it into remote memory, with the effect mediated through the anterior cingulate cortex rather than the hippocampus.

The paper shows that persistent PKMζ increases in specific hippocampal neurons during LTP maintenance and spatial memory storage, indicating its role in long-term memory.