Panayiotis Tsokas

PKMζ-PKC{iota}/{lambda} double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory

The paper shows that PKC{iota}/{lambda} compensates for PKM{zeta} in maintaining hippocampal late-LTP and spatial memory when PKM{zeta} is absent.

PKMζ-KIBRA interactions, molecular turnover, and memory

The paper investigates how KIBRA-PKMζ interactions sustain long-term memory despite molecular turnover by forming oligomers that continuously incorporate new molecules.

Increased protein kinase Mζ expression by Minocycline and N-acetylcysteine restoreslate-phase long-term potentiation and spatial learning after closed head injury in mice

MN12 treatment increases PKMζ expression, restoring LTP and spatial learning in mice with closed head injury.

Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage

The paper shows that persistent PKMζ increases in specific hippocampal neurons during LTP maintenance and spatial memory storage, indicating its role in long-term memory.