Molecular BiologyNucleic Acids ResearchPeer-reviewed
Optimized nickase- and nuclease-based prime editing in human and mouse cells
Fatwa Adikusuma, Caleb Lushington, Jayshen Arudkumar…·Paul Quinton Thomas
This paper develops PEA1 plasmids and PE-nuclease systems for efficient prime editing in human and mouse cells, achieving high editing efficiency in some cell lines and fetal mice.