Darby W. Kozan

This study shows that loss of asgr1a in zebrafish leads to excess dietary cholesterol excretion rather than hepatic accumulation, suggesting a role for ASGR1 in cholesterol metabolism.

The paper compares transposon mutagenesis methods in yeast to infer gene essentiality, finding biases in insertion sites and recommending transposon choices for accurate essentiality prediction.