Author

Catherine M. O’Connell

University of North Carolina at Chapel HillORCID 0000-0002-8229-684XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Toni L. DarvilleiD· 4 shared Xiaojing ZhengiD· 4 shared Bryce DuncaniD· 2 shared Camille CampbelliD· 2 shared Kacy S. YountiD· 2 shared Sangmi JeongiD· 2 shared Tammy S. TollisoniD· 2 shared Xinxia PengiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersMicrobiology

Toni L. DarvilleORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mycoplasmal endosymbionts of Trichomonas vaginalis are associated with reduced risk for Chlamydia trachomatis endometrial infection in asymptomatic, coinfected, women.

Xuejun Sun, Kacy S. Yount, Nefer N Batsuli, Camille Campbell, Sangmi Jeong, Tammy S. Tollison, Xinxia Peng, Toni L. Darville, Xiaojing Zheng, Catherine M. O’Connell

bioRxiv · Sep 3, 2026 · PreprintMicrobiology

Genetic diversity of Collaborative Cross mice enables the establishment of a novel Chlamydia muridarum female genital tract infection model

Toni L. Darville, Jenna Girardi, Taylor B. Poston, Camille Campbell, Xuejun Sun, Yajing B. Hao, Y J Zhang, Chuwen Liu, Bryce Duncan, Fei Zou, Catherine M. O’Connell, Xiaojing Zheng

This study uses Collaborative Cross mice to identify host genetic factors influencing Chlamydia muridarum infection outcomes, revealing distinct genetic pathways for bacterial burden and pathology.

Infection and Immunity · May 5, 2026Peer-reviewedImmunology

miRNA/mRNA analysis of increased TGF-β pathways drive epithelial-mesenchymal transition and regulatory T cell differentiation

Toni L. Darville, Xuejun Sun, Yu Zhang, Catherine M. O’Connell, Neha V. Mokashi, Weiming Tang, Aakash Bhardwaj, Bryce Duncan, Charles W. Andrews, Harold C. Wiesenfeld, Xiaojing Zheng

The paper analyzes miRNA and mRNA expression in endometrial biopsies to show increased TGF-β pathways drive EMT and Treg differentiation in Chlamydia infection.

Frontiers in Immunology · Mar 6, 2026Peer-reviewedGenomics

Cervicovaginal microbial features predict Chlamydia trachomatis spread to the upper genital tract of infected women

Sangmi Jeong, Tammy S. Tollison, Hayden N. Brochu, Hsuan Chou, Ian Huntress, Kacy S. Yount, Xiaojing Zheng, Toni L. Darville, Catherine M. O’Connell, Xinxia Peng

Infection and Immunity · Aug 12, 2025Peer-reviewedMicrobiology