Xiaojing Zheng

This study uses Collaborative Cross mice to identify host genetic factors influencing Chlamydia muridarum infection outcomes, revealing distinct genetic pathways for bacterial burden and pathology.

The paper analyzes miRNA and mRNA expression in endometrial biopsies to show increased TGF-β pathways drive EMT and Treg differentiation in Chlamydia infection.

The paper curates a collection of transcriptome datasets from viral respiratory inoculation and vaccination studies to enable reanalysis of transcriptional responses in blood and nasal samples.

The paper constructs a temporal atlas of human blood leukocyte changes after respiratory virus infection, showing shared immune responses and virus-specific kinetics.

This study evaluates batch correction methods for integrating microarray and RNA-seq data, finding that limma provides the best balance of Type I error control and power for differential expression analysis.

ARTdeConv improves cell type deconvolution by addressing limitations in existing methods, showing better performance in simulations and real data compared to other approaches.

This paper introduces a method to test mediation effects of multiple SNPs on various phenotypic outcomes, showing high power gains in simulations and real data applications.

The paper introduces SMUT, a method to test mediation effects of multiple SNPs on phenotypes, showing improved power and identifying known mediators in a real dataset.