Zarah Forsberg

Conserved copper(I)-binding auxiliary domains link virulence-associated LPMOs to copper homeostasis in the intestinal environment

The paper shows that copper(I)-binding domains in LPMOs from intestinal pathogens are linked to virulence and copper homeostasis in the gut.

Redox robustness drives LPMO evolution

This study investigates how evolutionary pressures shaped LPMO enzymes to enhance redox robustness through copper re-oxidation and radical scavenging mechanisms.

Functional characterization of multi-domain LPMOs from marine Vibrio species reveals modulation of enzyme activity by domain-domain interactions

The paper functionally characterizes multi-domain LPMOs from marine Vibrio species, revealing that domain-domain interactions modulate enzyme activity by regulating copper site accessibility.

Discovery and characterization of a copper-binding carbohydrate-binding module (CBM) regulating the activity of lytic polysaccharide monooxygenases

The paper identifies a copper-binding CBM2 module that regulates LPMO activity by scavenging free copper and interacting with the LPMO's catalytic site, preventing oxidative damage.