Fred A. Wright

This study systematically evaluates 1,538 ECHA decisions on read-across adaptations in REACH testing proposals, finding that 49% were accepted with group read-across having higher acceptance odds.

The paper presents AIDA, a diverse single-cell RNA-seq atlas of immune cells, revealing sub-continental diversity impacts on immune cell properties and identifying functional genetic variants.

TwinEQTL provides a fast and powerful method for eQTL and GWAS analysis in twin studies by splitting twin samples and combining results with minimal power loss.

The paper improves genotype imputation for CF patients using the TOPMed reference panel and a CF-specific imputation panel, enhancing marker coverage and PRS accuracy.

The paper presents a large ASE resource from GTEx v8 with 431 million SNP-level and 153 million haplotype-level measurements, and extends phASER to estimate cis regulatory variant effect sizes.

The paper quantifies protein levels across 32 human tissues and compares them to transcriptome data, revealing insights into post-transcriptional regulation and disease mechanisms.

The paper introduces MTCA, a method for accurate statistical testing of trait-genomic feature associations, handling maxima and sums of r2 statistics while accounting for correlations.

This study partitions the heritability of local and distal gene expression regulation across 15 human tissues, identifying enriched functional categories and tissue-specific patterns.