Andrey A. Shabalin

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

This paper conducts a multi-ancestry GWAS meta-analysis of suicide attempt, identifying 12 genome-wide significant loci and finding shared genetic risks with ADHD, smoking, and risk tolerance.

TwinEQTL provides a fast and powerful method for eQTL and GWAS analysis in twin studies by splitting twin samples and combining results with minimal power loss.

The paper examines genetic overlaps between suicide-related behaviors and substance use disorders using GWAS summary statistics and finds significant genetic correlations but little evidence of causation.

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

This study conducts a genome-wide association meta-analysis of childhood aggression across multiple raters, instruments, and ages, identifying genetic correlations with various traits but no genome-wide significant SNPs.

The paper identifies five rare SNPs associated with suicide death using genetic data from the USGRS and controls, highlighting their potential role in suicide risk and related biological processes.

This paper conducts a genome-wide association study of suicide death and shows polygenic scores predict suicide case-control status and related psychiatric traits.

This study finds that subthreshold psychosis symptoms in a population-based cohort are associated with genetic risks for schizophrenia, ADHD, autism, and neuroticism, with notable sex differences.

This paper applies genetic path analysis to adjust for pleiotropy in Mendelian randomization, finding education protects against BMI and smoking initiation.

The paper identifies 207 genes associated with completed suicide using genomic data from 43 high-risk Utah families, finding four significant variants linked to suicide risk.

This study identifies novel methylation associations with major depressive disorder using cell-type-specific methylome-wide association studies in brain and blood samples.

The paper identifies TCF4 binding sites and their association with schizophrenia risk genes, showing TCF4 regulates neural development genes and interacts with SZ-related loci.

The paper develops S-PrediXcan to compute gene expression associations from GWAS summary data and applies it to 44 GTEx tissues and 100+ phenotypes, finding tissue-specific effects and colocalized associations.