Systems BiologyiSciencePeer-reviewed
Emergent signal execution modes in biochemical reaction networks calibrated to experimental data
Oscar O. Ortega, Mustafa Ozen, Blake A. Wilson…·Carlos F. Lopez
The paper introduces PyDyNo, a framework to identify dominant reaction paths in biochemical networks using Bayesian parameter optimization, revealing distinct signal execution modes in apoptosis and JAK2/STAT5 networks.