David Kleinfeld

The paper shows neurons entrain an intrinsic arteriole rhythm, shaping blood distribution and vascular responses through frequency-dependent mechanisms.

The paper develops Ca2+-independent lactate biosensors for multiplexed in vivo imaging of extracellular lactate dynamics alongside neuronal activity.

The paper examines the organization of axons around cortical vasculature in mice, finding that axons form micro-tracts around capillaries, which may facilitate neurovascular coupling.

This study shows that cerebral arteriole vasomotion persists during elimination of Mayer waves, suggesting intrinsic generation of ~0.1 Hz oscillations in brain arteries.

This study identifies a hypoxia-sensitive pathway in the RVLM that modulates cerebral blood flow through disynaptic connections to the cortex.

The paper develops two variants of a glutamate indicator with enhanced sensitivity and tailored deactivation rates for studying synaptic transmission in vivo.

The paper improves the GraFT algorithm for functional calcium imaging by enhancing speed and accessibility through efficient solvers, compressive sensing, and a graphical user interface.

The paper maps brainstem neural activity related to breathing, licking, and swallowing in mice, revealing coordinated rhythms and a premotor network involved in orofacial movements.

The paper shows that hemodynamic responses in the cortex are influenced by neuromodulators like norepinephrine, with distinct impulse response functions for different neuromodulatory signals.

CellBoost reduces annotation labor in neuroanatomy by combining human judgment and machine learning, achieving accuracy comparable to human agreement while decreasing time by up to ten-fold.

The paper shows that a behavioral state change alters the phase of motor output relative to sniffing during exploratory behavior in rats.

This study shows that a cortex-independent internal model in the red nucleus can control voluntary orofacial motor actions without requiring peripheral feedback or motor cortex.

This paper develops improved glutamate indicators with faster activation kinetics and better synaptic localization for imaging synaptic transmission in neurons.

This paper describes the construction and use of an adaptive optics two-photon microscope with direct wavefront sensing to improve resolution in deep brain imaging.

The paper demonstrates that transient hyperglycemia enhances thrombo-inflammatory responses in cortical venules when combined with physical vessel disruption in mice.

The paper develops an all-optical method to study neuropeptide volume transmission in mouse neocortex, finding faster SST transmission in a chemically degraded extracellular matrix.

This study maps the paralemniscal vibrissa pathway in rodents, showing it connects to brainstem autonomic regions and forebrain emotional centers, with GABAergic inhibition in the Kolliker-Fuse nucleus.

This paper introduces CBF-fMRI using phase-contrast imaging to map blood velocity in single vessels, showing comparable velocity changes in arterioles and venules.

This study shows that mosaic inactivation of ccm2 in zebrafish leads to abortive intussusceptive angiogenesis, causing multi-cavernous vascular malformations similar to human cerebral cavernous malformations.

The paper constructs an adult orofacial premotor atlas in mice by tracing premotor circuits and registering them to the Allen Mouse CCF, revealing spatial organization and coordination of motor nuclei.

This paper describes a new mechanism for forming large diameter blood vessels through endothelial struts that act as scaffolds during vasculogenesis.

This paper demonstrates a method to selectively open the blood-brain barrier using light-stimulated nanoparticles targeting tight junctions, enabling macromolecule and gene therapy vector delivery without neurotoxicity.