Zhenpeng Qin

This study develops photoswitchable nanovesicles for controlled in vivo neuropeptide delivery, showing they modulate hippocampal circuit dynamics and social behavior in mice.

This paper identifies Atto 643 carboxy as a highly specific fluorescent dye for astrocyte labeling with minimal oligodendrocyte cross-reactivity and improved specificity compared to SR101.

The paper develops a method to image the entire brain extracellular matrix in live tissue using a protein-reactive dye, enabling visualization of ECM structures in various brain conditions.

The paper develops an all-optical method to study neuropeptide volume transmission in mouse neocortex, finding faster SST transmission in a chemically degraded extracellular matrix.

This paper presents a minimally invasive method to deliver peptides to the spinal cord for behavior modulation using optical stimulation of nanoparticles, demonstrating efficacy in inducing itching in mice without genetic modification.

This paper demonstrates a method to selectively open the blood-brain barrier using light-stimulated nanoparticles targeting tight junctions, enabling macromolecule and gene therapy vector delivery without neurotoxicity.