Cancer BiologyScience AdvancesPeer-reviewed
SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy
Gonzalo Rodríguez‐Berriguete, Purusotha Thambiayah, Alessandro Cicconi…·Geoff Stuart Higgins
The paper identifies SHLD2 loss as a vulnerability that enhances radiosensitisation when combined with Polθ inhibition in cancer cells.
DOI 10.1126/sciadv.aeb4508