Author

Geoff Stuart Higgins

University of OxfordORCID 0000-0003-3072-909XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1

Frequent Co-Authors

Gonzalo Rodríguez‐BerrigueteiD· 2 shared Nicole MachadoiD· 2 shared Alastair D.G. LambiD· 1 shared Alessandro CicconiiD· 1 shared Asmita Thapa· 1 shared Aurora CeruttiiD· 1 shared Bethany Rebekah Hill· 1 shared Célia GotorbeiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Gonzalo Rodríguez‐BerrigueteORCID

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Author profile →

3 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedJun 12, 2026

SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy

Gonzalo Rodríguez‐Berriguete, Purusotha Thambiayah, Alessandro Cicconi…·Geoff Stuart Higgins

The paper identifies SHLD2 loss as a vulnerability that enhances radiosensitisation when combined with Polθ inhibition in cancer cells.

DOI 10.1126/sciadv.aeb4508

humangenetic perturbation / CRISPR

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Cancer BiologyCell Death and DiseasePeer-reviewedJul 22, 2025

UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment by regulating tumour cell fate

Tatsuya Suwa, Kelly SW. Lee, Ian J. Chai…·Monica M. Olcina

This study shows hypoxia induces intracellular C5aR1 via UPR, promoting tumour cell survival by regulating autophagy and apoptosis.

6 citations

humanexperimental assay

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GenomicsbioRxivPreprintSep 4, 2023

Molecular analysis of archival diagnostic prostate cancer biopsies identifies genomic similarities in cases with progression post-radiotherapy, and those with de novo metastatic disease.

Philip Vincent Charlton, Dawn O’Reilly, Yiannis Philippou…·Richard J. Bryant

DOI 10.1101/2023.09.04.555868

humanbulk RNA-seq

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