Author

Purusotha Thambiayah

University of OxfordORCID 0000-0002-3317-3237Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Alessandro CicconiiD· 1 shared Asmita Thapa· 1 shared Aurora CeruttiiD· 1 shared Bethany Rebekah Hill· 1 shared Célia GotorbeiD· 1 shared David NderituiD· 1 shared Eeson RajendraiD· 1 shared Geoff Stuart HigginsiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alessandro CicconiORCID

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1 paper

Recent·Most cited

SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy

Gonzalo Rodríguez‐Berriguete, Purusotha Thambiayah, Alessandro Cicconi, Nicole Machado, Célia Gotorbe, David Nderitu, Wei‐Chen Cheng, Gerissa Fowler, Marie Laure Boursier, Aurora Cerutti, Vera V. Grinkevich, Bethany Rebekah Hill, Katjuša Koler, Sophie Alice Langdon, Jayesh B. Majithiya, , Geoff Stuart Higgins

The paper identifies SHLD2 loss as a vulnerability that enhances radiosensitisation when combined with Polθ inhibition in cancer cells.

Science Advances · Jun 12, 2026Peer-reviewedCancer Biology