Author

Ismael Plaza-G.A.

IMDEA NanoscienceORCID 0000-0002-8271-2532Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Borja IbarraiD· 2 shared Grzegorz L. CiesielskiiD· 2 shared Rafael Fernández-LeiroiD· 2 shared Samuel Miguez-AmiliD· 2 shared A. Grande-GarcíaiD· 1 shared Carlos Chacón-SáncheziD· 1 shared Emma Areán-UlloaiD· 1 shared Ester Casajús-PelegayiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Borja IbarraORCID

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2 papers

Recent·Most cited

A dedicated motif in human polymerase gamma enables DNA synthesis through replication roadblocks

Samuel Miguez-Amil, A. Grande-García, Ismael Plaza-G.A., María Moreno‐Morcillo, Ester Casajús-Pelegay, Emma Areán-Ulloa, Carlos Chacón-Sánchez, Grzegorz L. Ciesielski, Borja Ibarra, Rafael Fernández-Leiro

This study identifies a Template Stabilising Motif in human Polγ that enables DNA synthesis through replication roadblocks by stabilizing template engagement.

bioRxiv · Sep 28, 2026 · PreprintMolecular Biology

Auto-regulation of the real-time kinetics of the human mitochondrial replicative helicase

Ismael Plaza-G.A., María Ortiz-Rodríguez, Seth P. Buchanan, Samuel Miguez-Amil, Kateryna M. Lemishko, Fernando Moreno‐Herrero, Rafael Fernández-Leiro, Grzegorz L. Ciesielski, Borja Ibarra

This study investigates the real-time kinetics of Twinkle, a human mitochondrial helicase, and identifies regulatory roles of its N-terminal ZBD and C-terminal tail, along with mtSSB interactions.

Nature Communications · Jul 1, 2025Peer-reviewedBiophysics