Samuel Miguez-Amil

This study identifies a Template Stabilising Motif in human Polγ that enables DNA synthesis through replication roadblocks by stabilizing template engagement.

This study investigates the real-time kinetics of Twinkle, a human mitochondrial helicase, and identifies regulatory roles of its N-terminal ZBD and C-terminal tail, along with mtSSB interactions.

This study identifies PrimPol as a key player in ICL traverse, showing its primase activity is required for DNA damage tolerance and that its absence increases sensitivity to ICL-inducing drugs.