Shobana Sekar

All2: A tool for selecting mosaic mutations from comprehensive multi-cell comparisons

All2 filters mosaic mutations from multi-cell comparisons by classifying variants as germline, mosaic, or false positive, improving sensitivity and reducing false positives in whole genome and exome analysis.

Comprehensive identification of somatic nucleotide variants in human brain tissue

This study identifies somatic SNVs in non-cancerous human brain tissues and establishes best practices for detecting low-frequency variants.

ACValidator: a novel assembly-based approach for in silico validation of circular RNAs

ACValidator validates circRNAs by assembling reads around junctions and aligning contigs to detect back-spliced junctions, achieving high sensitivity and specificity in simulated and experimental datasets.

Circular RNA expression and regulatory network prediction in posterior cingulate astrocytes in elderly subjects

The paper identifies circRNAs and their regulatory networks in posterior cingulate astrocytes from elderly subjects, finding enriched immune response pathways.