Guy A. Caldwell

This study shows that dopamine levels influence both neurodegeneration and lifespan in a C. elegans Parkinson's model by modulating -syn toxicity and proteostasis.

This study identifies TNK2 as a regulator of dopamine and epigenetic processes in Parkinson's disease, showing that mutations in TNK2 affect neuroprotection through interactions with RNAi and dopamine transport.

This paper identifies SID genes that modulate dopaminergic neurodegeneration in C. elegans by affecting RNA interference and microRNA activity.

The paper investigates how nicotine protects dopaminergic neurons in C. elegans by activating mitochondrial stress pathways involving PINK-1 and D3 receptors.