Author

J. Brucker Nourse

University of AlabamaORCID 0000-0002-8565-8615Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:rat· 1

Frequent Co-Authors

Guy A. CaldwelliD· 3 shared Kim A. CaldwelliD· 3 shared Kylie PeteriD· 2 shared Shannon N. RusselliD· 2 shared Abdelrahaman KarmiiD· 1 shared Adi Danfi MaromiD· 1 shared Anthony L. GaetaiD· 1 shared Candice M. KeoghiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Guy A. CaldwellORCID

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3 papers

Recent·Most cited

Integrated Regulation of Dopaminergic and Epigenetic Effectors of Neuroprotection in Parkinson's Disease Models

J. Brucker Nourse, Shannon N. Russell, Nathan A. Moniz, Kylie Peter, Lena M. Seyfarth, Madison Scott, Hana Park, Kim A. Caldwell, Guy A. Caldwell

This study identifies TNK2 as a regulator of dopamine and epigenetic processes in Parkinson's disease, showing that mutations in TNK2 affect neuroprotection through interactions with RNAi and dopamine transport.

Proceedings of the National Academy of Sciences · Feb 6, 2023Peer-reviewedNeuroscience

Systemic RNA interference-defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans

Anthony L. Gaeta, J. Brucker Nourse, Karolina Willicott, Luke E. McKay, Candice M. Keogh, Kylie Peter, Shannon N. Russell, Shusei Hamamichi, Laura A. Berkowitz, Kim A. Caldwell, Guy A. Caldwell

This paper identifies SID genes that modulate dopaminergic neurodegeneration in C. elegans by affecting RNA interference and microRNA activity.

PLoS Genetics · Aug 19, 2022Peer-reviewedGenetics

Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress

J. Brucker Nourse, Gilad Harshefi, Adi Danfi Marom, Abdelrahaman Karmi, Hagit Cohen Ben-Ami, Kim A. Caldwell, Guy A. Caldwell, Millet Treinin

The paper investigates how nicotine protects dopaminergic neurons in C. elegans by activating mitochondrial stress pathways involving PINK-1 and D3 receptors.

iScience · Jan 1, 2020Peer-reviewedNeuroscience