Widely Used Calculations of Intracranial Volume Provide Inaccurate Estimates in Developmental Cohorts: Evidence and Solutions for the Neuroimaging Community
Amalia M. Skyberg, Ava Reck, Jolinda C. Smith, Benjamin T. Newman, Madeleine Goldberg, T. Jason Druzgal, John D. Van Horn, Jennifer H. Pfeifer
This study shows that FreeSurfer's eTIV estimates are inaccurate in developmental cohorts and proposes solutions with newer versions.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience