Elisabeth B. Binder

Across 15 cohorts (birth to 24 years), 20 epigenetic clocks and eight brain age models predicted chronological age modestly, stabilizing by middle childhood; their age residuals were weakly associated.

The paper identifies contmeQTLs linking childhood adversity to epigenetic changes in immune cells, which are associated with disease risk and inflammatory profiles.

The paper describes the curation and initial analysis of molecular genetic and epigenetic data from the TwinLife study, highlighting associations between polygenic scores and attrition, and stability of epigenetic clocks in saliva.

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This study investigates how early life stress affects brain function and behavior in mice, revealing sex-specific differences in neurobiological outcomes.

RAMEN dissects gene-environment contributions to DNA methylome variability in cord blood, finding genetics explains the largest proportion of DNAme variance.

This study examines differences between Infinium MethylationEPIC v1 and v2, showing high array-level concordance but probe-level variation, and recommends accounting for version differences in analyses.

This paper identifies SORCS3 as a novel genetic locus associated with panic disorder through a genome-wide association study in the FinnGen study and validates it in independent samples.

This study examines genetic and environmental influences on epigenetic aging variance across adolescence and young adulthood using twin data and four aging estimators.

This study shows chronic glucocorticoid exposure alters lineage specification in human neural organoids by priming inhibitory neuron fate through transcription factors like PBX3.

The paper examines FKBP5 DNA methylation in schizophrenia and finds lower methylation in a proximal enhancer linked to higher gene expression and age.

This paper integrates 36 single-cell transcriptomics datasets from human neural organoids into a unified atlas to assess cell type coverage and compare organoid protocols with primary brain tissue.

This study investigates the differential dynamics and roles of FKBP51 isoforms in response to glucocorticoids using in vitro models and human blood cells, highlighting their distinct functions and implications for targeted therapies.

This paper develops two epigenetic clocks for rhesus macaques and finds that early life adversity, specifically infant maltreatment, is associated with epigenetic age acceleration.

The paper identifies molecular and anatomical diversity in human cortical astrocytes and links adversity and glucocorticoid signalling to glutamate-related synaptic dysfunction in psychiatric disorders.

This study investigates the association between HTT CAG repeat size variations and psychiatric phenotypes and basal ganglia structure in non-HD ranges, finding age-dependent effects on anxiety and depression risk.

This study shows glucocorticoids increase specific basal progenitors via ZBTB16, leading to more neurons and linking to educational attainment and brain structure.

This study identifies alternative polyadenylation (APA) as a molecular mechanism linking polygenic risk for schizophrenia to synaptic impairments through functional analysis in induced neurons.

The paper examines how stress-induced brain responses relate to BMI in women, finding that specific brain regions predict BMI and that endocrine factors, not inflammation, are linked to these changes.

The paper investigates how genetic variations affecting endosomal sorting processes influence neural responses in the reward system using fMRI and gene set analysis.

The paper introduces DiffBrainNet, a framework combining differential expression and network analysis to study glucocorticoid responses in mouse brain regions, revealing gene-level and network-level insights.

The paper identifies spatio-temporal brain network reconfigurations during stress that predict negative affectivity but not disorder diagnosis.

The paper identifies sex-specific genetic regulators of the blood transcriptome response to glucocorticoid receptor activation and links them to depression risk in a cohort of children and adolescents.

The paper presents a statistical framework for experimental design and power analysis in single cell RNA-seq studies, showing that higher power is achieved with shallow sequencing of more cells per individual.

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

The paper uses targeted metabolomics to analyze changes in acylcarnitines, amines, and lipids in response to citalopram/escitalopram treatment in MDD patients, identifying metabolic correlates of treatment response.

The paper investigates how psychiatric disease and aging affect FKBP5 expression in the human brain, identifying supragranular neurons as key targets.

This paper tests if a machine learning model predicting stress from hippocampal connectivity generalizes to psychosocial stress, finding limited generalizability.

This study identifies DNA methylation sites at birth associated with ADHD symptoms later in childhood, but finds no such associations at school age.