Regulatory T cells epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity
Tyler R. Colson, James J. Cameron, Hayley I. Muendlein, Mei-An Nolan, Jamie L. Leiriao, James H. Kim, Alexander N. Poltorak, Xudong Joshua Li
This study reprograms autoreactive effector T cells into stable regulatory T cells using epigenetic modification, showing improved efficacy in treating autoimmune neuroinflammation.
bioRxiv · Jul 24, 2025 · PreprintImmunology