Author

Tyler R. Colson

Tufts UniversityORCID 0000-0001-7124-2208Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

James J. CameroniD· 2 shared Xudong Joshua LiiD· 2 shared Alexander N. PoltorakiD· 1 shared Hayley I. MuendleiniD· 1 shared James H. KimiD· 1 shared Jamie L. LeiriaoiD· 1 shared Mei-An NolaniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

James J. CameronORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJan 14, 2026

Dot1L licenses DNA demethylation to establish regulatory T cell identity

James J. Cameron, Tyler R. Colson, Xudong Joshua Li

This study identifies Dot1L-mediated H3K79 methylation as essential for Treg-specific DNA demethylation, which is critical for Treg identity and function.

1 citation

mouseDNA methylation

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ImmunologybioRxivPreprintJul 24, 2025

Regulatory T cells epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity

Tyler R. Colson, James J. Cameron, Hayley I. Muendlein…·Xudong Joshua Li

This study reprograms autoreactive effector T cells into stable regulatory T cells using epigenetic modification, showing improved efficacy in treating autoimmune neuroinflammation.

DOI 10.1101/2025.07.24.665398

mouseexperimental assay

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