Molecular BiologybioRxivPreprint
Dynamic Supercoiling Sponsors Transcription Amplification by MYC
Rajeev Jha, Fedor Kouzine, Bo Wang…·David Levens
The paper develops a genetic tool to distinguish MYC's activation from amplification of gene expression and reveals that DNA supercoiling stabilizes pre-initiation complexes, enhancing MYC-driven transcription.
DOI 10.64898/2026.01.19.700398