Author

James D. Phelan

National Institutes of HealthORCID 0000-0001-8950-2485Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Aaliyah BattleiD· 1 shared Arnold BolomskyiD· 1 shared Björn HäupliD· 1 shared Bo WangiD· 1 shared Brian A. LewisiD· 1 shared Callie K. VanWinkleiD· 1 shared David LevensiD· 1 shared Elizabeth HilliD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Aaliyah BattleORCID

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2 papers

Recent·Most cited

Cancer BiologyBlood Cancer DiscoveryPeer-reviewedAug 31, 2026

Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation

Lin Zhang, Arnold Bolomsky, Omar S. Al‐Odat…·Ryan M. Young

This study identifies phosphorylation as a mechanism protecting oncogenic RAS from LZTR1-mediated degradation, with implications for targeting RAS stability in hematologic cancers.

DOI 10.1158/2643-3230.bcd-26-0028

humanproteomics

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJan 19, 2026

Dynamic Supercoiling Sponsors Transcription Amplification by MYC

Rajeev Jha, Fedor Kouzine, Bo Wang…·David Levens

The paper develops a genetic tool to distinguish MYC's activation from amplification of gene expression and reveals that DNA supercoiling stabilizes pre-initiation complexes, enhancing MYC-driven transcription.

DOI 10.64898/2026.01.19.700398

experimental assay

𝕏 PostBluesky