Author

Subhendu Das

National Cancer InstituteORCID 0000-0003-1677-3844Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

David LevensiD· 2 shared Bo WangiD· 1 shared Brian A. LewisiD· 1 shared Fedor KouzineiD· 1 shared James D. PhelaniD· 1 shared John M. SedivyiD· 1 shared Kris YlayaiD· 1 shared Rajeev JhaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

David LevensORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJan 19, 2026

Dynamic Supercoiling Sponsors Transcription Amplification by MYC

Rajeev Jha, Fedor Kouzine, Bo Wang…·David Levens

The paper develops a genetic tool to distinguish MYC's activation from amplification of gene expression and reveals that DNA supercoiling stabilizes pre-initiation complexes, enhancing MYC-driven transcription.

DOI 10.64898/2026.01.19.700398

experimental assay

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 28, 2025

A tumorigenesis threshold for endogenous Myc revealed by dosage-compensation for Myc haploinsufficiency in the absence of p53.

Xiaozhong Bao, Zied Abdullaev, Subhendu Das…·David Levens

This study shows that reducing endogenous Myc levels in p53-deficient mice extends tumor-free survival and that tumors compensate by increasing Myc dosage or expression.

DOI 10.1101/2025.07.28.667174

mouseexperimental assay

𝕏 PostBluesky