David Levens

Dynamic Supercoiling Sponsors Transcription Amplification by MYC

The paper develops a genetic tool to distinguish MYC's activation from amplification of gene expression and reveals that DNA supercoiling stabilizes pre-initiation complexes, enhancing MYC-driven transcription.

Connecting spatial regions to clinical phenotypes by transferring knowledge from bulk patient data

SpacePhenotyper transfers predictive gene expression-phenotype relationships from bulk data to spatial transcriptomics data to analyze clinical phenotypes in spatial regions of tumors.

A tumorigenesis threshold for endogenous Myc revealed by dosage-compensation for Myc haploinsufficiency in the absence of p53.

This study shows that reducing endogenous Myc levels in p53-deficient mice extends tumor-free survival and that tumors compensate by increasing Myc dosage or expression.

Transcriptional repression of Myc underlies AGO1's tumour suppressor function

This study identifies AGO1 as a tumour suppressor in Drosophila that represses Myc transcription, inhibiting cell and tissue growth through direct transcriptional repression.

Psi promotes Drosophila wing growth through transcriptional repression of key developmental networks

The paper identifies Psi as a repressor of developmental pathways that promotes Drosophila wing growth by both activating Myc and repressing growth inhibitors.