Charlène Raclot

This study examines how mutations in the N-terminal domain of SARS-CoV-2 Spike affect antigenic properties and immune escape, finding that structural flexibility and loss of heme-metabolite interaction reduce antibody neutralization.

The paper identifies functional roles of human KZFPs through overexpression screening and integrative analysis, revealing diverse mechanisms in cellular homeostasis.

The paper identifies the Lipid Oxygen Radical Defense (LORD) pathway and shows it is epigenetically controlled, affecting oxidative stress and ferroptosis.

The paper shows ZNF93, a primate-specific protein, regulates APOBEC3B and influences cancer progression by affecting DNA synthesis and genomic stability.

This study identifies evolutionarily recent transcription factors that influence human cell cycle regulation by affecting gene expression and replication timing.

This study shows that SCAN domain zinc-finger proteins bind transposon sequences and anchor nucleosomes, affecting chromatin structure and regulatory states.

The paper shows that a transposable element-derived domain in KRAB zinc-finger proteins enables new transcription factor functions through trimerization and condensate formation.