Author

Claudia Gentile

Montreal Clinical Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 4 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Research Focus:gene regulatory network inference· 4 Organism:mouse· 4 Assay:ChIP-seq· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2

Frequent Co-Authors

Marie KmitaiD· 4 shared Alexandre MayraniD· 3 shared Fanny Guerard-Millet· 3 shared Adrian Gerold SacheriD· 1 shared Alessandra Pizzella· 1 shared Alessandro UsielloiD· 1 shared Alexander Wang YingiD· 1 shared Anna Di Maio· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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4 shared papersDevelopmental Biology

Marie KmitaORCID

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6 papers

Recent·Most cited

mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion

Claudia Gentile, William W. Feng, Sean M. Lenahan, Alexander Wang Ying, Daren C. Card, Florence T.H. Wu, Nhu‐An Pham, Nikolina Radulovich, Pinjiang Mary Cao, K. Hueniken, Quan Li, Ming‐Sound Tsao, JOSEPH S. KULESZA, Madeline M. Hinkley, Lishu Liao, , Cigall Kadoch

This study shows that inhibiting mSWI/SNF complexes enhances the effectiveness of KRAS inhibitors in lung cancers by reversing epithelial-mesenchymal transition resistance.

bioRxiv · Mar 1, 2026 · PreprintCancer Biology

Deep Brain Stimulation rescues the homeostasis disruption of circulating D- and L-amino acids level in men with Parkinson's Disease

Tommaso Nuzzo, Federica Carrillo, Marcello Serra, Claudia Gentile, Anna Di Maio, Alessandra Pizzella, Sara Pietracupa, Nicola Modugno, Francesco Errico, Teresa Esposito, Alessandro Usiello

This study shows that Deep Brain Stimulation (STN-DBS) restores circulating D- and L-amino acid levels in male Parkinson's patients, unlike L-DOPA therapy, and suggests these amino acids as potential early biomarkers.

Neurobiology of Disease · Oct 20, 2025Peer-reviewedNeuroscience

Liebenberg syndrome severity arises from variations in Pitx1 locus topology and ectopically transcribing cells

Olimpia Bompadre, Raquel Rouco, Fabrice Darbellay, Antonella Rauseo, Fanny Guerard-Millet, Claudia Gentile, Marie Kmita, Guillaume Andrey

This study shows that variations in enhancer-promoter interactions at the Pitx1 locus lead to pathogenic activation in variable cell proportions, defining phenotypic severity in Liebenberg syndrome.

Nature Communications · Jul 9, 2025Peer-reviewedDevelopmental Biology

Polycomb Repressive Complexes occupancy reveals PRC2-independent PRC1 critical role in the control of limb development

Fanny Guerard-Millet, Claudia Gentile, Racheal Paul, Alexandre Mayran, Marie Kmita

The paper shows that PRC2 inactivation has minimal effect on PRC1 occupancy in developing limbs, highlighting the critical role of PRC2-independent PRC1 in gene regulation during limb development.

bioRxiv · Oct 28, 2021 · PreprintDevelopmental Biology

Analysis of Polycomb Repressive Complexes binding dynamics during limb development reveals the prevalence of PRC2-independent PRC1 occupancy

Claudia Gentile, Alexandre Mayran, Fanny Guerard-Millet, Marie Kmita

The paper analyzes PRC1 and PRC2 binding dynamics during limb development, finding that many PRC-bound promoters are occupied exclusively by PRC1, independent of PRC2.

bioRxiv · Sep 21, 2020 · PreprintDevelopmental Biology

HOX13-dependent chromatin accessibility modulates the target repertoires of the HOX factors

Inès Desanlis, Yacine Kherdjemil, Alexandre Mayran, Yasser C Bouklouch, Claudia Gentile, Rushikesh Sheth, Rolf Zeller, Jacques Drouin, Marie Kmita

The paper shows HOX13 factors modulate HOXA11 target repertoire through chromatin accessibility, revealing a mechanism for HOX binding specificity.

bioRxiv · Oct 2, 2019 · PreprintDevelopmental Biology