C. J. Brown

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application toMdm2/X dual antagonists

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein

The paper designs and tests stapled peptides that inhibit DAXX, a protein involved in cancer, showing they enter cells and disrupt its interactions with other proteins.

Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE).

This paper develops a novel peptide aptamer that binds eIF4E's cap-binding site using PELE, showing nanomolar affinity and intracellular function modulation.

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

Ecosystem services in connected catchment to coast ecosystems: monitoring to detect emerging trends

The paper tests ecological indicators in a catchment-to-coast system to determine their response times to environmental change, finding they require over 10 years to detect trends.

Future carbon emissions from global mangrove forest loss

This study projects future CO2 emissions from global mangrove forest loss and identifies key regions for mitigation strategies.

Conformational ordering of intrinsically disordered peptides for targeting translation initiation

The paper develops bioactive peptides that modulate eIF4E binding by inducing conformational order in intrinsically disordered regions of eIF4G.

bioPROTACs as versatile modulators of intracellular therapeutic targets: Application to proliferating cell nuclear antigen (PCNA)

This paper introduces bioPROTACs as intracellular biologics for targeted protein degradation, demonstrating their effectiveness against PCNA with rapid degradation and functional effects.

Automating the analysis of fish abundance using object detection: optimising animal ecology with deep learning

This study demonstrates that deep learning outperforms human experts and citizen scientists in accurately and efficiently quantifying fish abundance from underwater footage.

Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled α-helical peptide modality

This paper combines macrocyclization and D-amino acid strategies to create an all-D helical peptide with improved target affinity and cellular activity.

Glycoproteome Analysis of Human Serum and Brain Tissue

The paper develops a glycoproteome analysis method to identify glycopeptides in human serum and brain tissue, revealing tissue-specific glycan diversity and biosynthetic pathway differences.

De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.

The assessment of fishery status depends on the condition of fish habitats

The paper assesses how changes in fish habitats affect fisheries stock status classifications and highlights the need for habitat data in fisheries management.

Tracing the influence of land-use change on water quality and coral reefs using a Bayesian model

This paper develops a Bayesian model to link land-use change to coastal water quality using satellite data, validated against underwater surveys in Fiji.