Aging is associated with a systemic length-driven transcriptome imbalance
Thomas Stoeger, Rogan A. Grant, Alexandra C. McQuattie‐Pimentel, Kishore Reddy Anekalla, Sophia S. Liu, Heliodoro Tejedor Navarro, Benjamin David Singer, Hiam Abdala‐Valencia, Michael Schwake, Marie‐Pier Tétreault, Harris Perlman, William E. Balch, Navdeep S. Chandel, Karen M. Ridge, Jacob Iasha Sznajder, , Luı́s A. Nunes Amaral
The paper identifies a systemic age-dependent transcriptome imbalance driven by transcript length across multiple species and shows its correlation with splicing factors and environmental stressors.
Nature Aging · Dec 9, 2022Peer-reviewedSystems Biology