Thomas Stoeger

The paper provides a comprehensive survey of the ubiquitin-proteasome system (UPS) and estimates its size and scope within the human proteostasis network.

The paper analyzes how research attention on disease-target relationships predicts clinical trial success using Open Targets data.

The paper identifies non-verifiable human cell lines in cancer research publications, finding 235 papers referring to 7 cell lines as independent entities despite lacking proper documentation.

The paper identifies a bias in gene selection between -omics experiments and publication, introduces a tool to find understudied genes, and demonstrates its application in vertebrate aging research.

The paper shows that gene length-dependent transcription decline, typically associated with aging, also occurs in response to various perturbations across many gene expression profiles.

The paper curates a list of 838 high-confidence components of the autophagy-lysosome pathway as part of a comprehensive effort to define the human proteostasis network.

The paper identifies a systemic age-dependent transcriptome imbalance driven by transcript length across multiple species and shows its correlation with splicing factors and environmental stressors.

The paper defines and annotates 959 genes comprising the human proteostasis network, focusing on translation, protein folding, and organelle-specific systems.

The paper screens gene function literature for nucleotide sequence errors, finding 712 papers with at least one wrongly identified sequence, which may misinform future therapies.