William E. Balch

This study identifies AA263 analogs that enhance ER proteostasis by targeting ER protein disulfide isomerases, correcting protein misfolding in disease models.

The paper identifies a systemic age-dependent transcriptome imbalance driven by transcript length across multiple species and shows its correlation with splicing factors and environmental stressors.

The paper uses a machine learning approach to analyze AAT variants and identifies critical residue interactions that balance function and misfolding, providing insights for therapeutic development.

The paper shows that modulating the Hsp70 chaperone system improves NPC1 protein trafficking and stability across diverse genotypes by altering spatial covariance tolerance.