Ke Hao

Chemosensory mechanisms of larval foraging and competitive advantage in the invasive mosquito Aedes albopictus

This study investigates chemosensory mechanisms in mosquito larvae, identifying functional variation in odorant receptors and mapping sensory neuron projections to understand competitive advantages in invasive species.

Context-specific eQTLs reveal causal genes underlying shared genetic architecture of critically ill COVID-19 and idiopathic pulmonary fibrosis

The paper identifies shared genetic variants between critically ill COVID-19 and idiopathic pulmonary fibrosis by integrating GWAS with context-specific eQTLs and transcriptomics.

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

Decoding the Variant-to-Function Relationship for LIPA, a Risk Locus for CAD

The paper links LIPA risk alleles to increased monocyte/macrophage LIPA expression, which exacerbates atherosclerosis through enhanced PU.1 binding and altered macrophage function.

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes

This study uses transcriptome-wide association analysis to identify 114 genes associated with coronary artery disease, including 18 novel genes, and shows they are enriched in lipid metabolism pathways.

Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

This study identifies placental DNA methylation changes linked to maternal smoking during pregnancy and their associations with birth outcomes using data from the PACE consortium.

Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19

The paper uses multi-omics approaches to identify genes and plasma proteins associated with COVID-19, finding ABO plasma protein as a causal risk factor.

Variation in Placental microRNA Expression Associates with Familial Cardiovascular Disease

The paper identifies microRNAs in placental tissue associated with familial cardiovascular disease using RNA sequencing and statistical modeling.

Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanisms

This study integrates Alzheimer’s disease GWAS with myeloid epigenomic data to identify risk enhancers and causal genes, implicating myeloid endolysosomal dysfunction in AD pathogenesis.

Placental microRNA Expression Associates with Birthweight through Control of Adipokines: Results from Two Independent Cohorts

The paper identifies miR-532 as a microRNA associated with birthweight percentile through regulation of adipokines in two independent cohorts.

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

This study identifies genetic effects on birth weight and their impact on cardio-metabolic traits, distinguishing fetal and maternal contributions.

Transcriptome-wide association studies: opportunities and challenges

This paper evaluates transcriptome-wide association studies (TWAS) for causal gene prioritization, showing its strengths and limitations in identifying causal genes at GWAS loci.

EnsembleCNV: An ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data

EnsembleCNV improves CNV detection and genotyping using SNP arrays, achieving high accuracy and sensitivity for downstream GWAS.

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

This study identifies a fetal genome-wide association signal near pro-inflammatory cytokine genes on 2q13 linked to gestational duration and preterm/postterm birth.

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s disease

This study identifies a haplotype lowering PU.1 expression in myeloid cells that delays Alzheimer’s disease onset by affecting gene expression and function.