This study constructs a high-resolution placental mQTL resource and investigates how placental DNA methylation relates to early- and later-life traits and their shared vulnerability.

medRxiv · Jul 9, 2026 · PreprintGenetic & Genomic Medicine

High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy

Haibin Guan, Jia Chen, Kirtan Kaur, Bushra Amreen, Corina Lesseur, Georgia Dolios, Syam S. Andra, Srinivasan Narasimhan, Divya Pulivarthi, Vishal Midya, Lot D. de Witte, Veerle Bergink, Anna‐Sophie Rommel, Lauren M. Petrick

Science of The Total Environment · Jun 1, 2025Peer-reviewedBioinformatics

Potentially causal associations between placental DNA methylation and schizophrenia and other neuropsychiatric disorders

Ariadna Cilleros‐Portet, Corina Lesseur, Sergi Marí, Marta Cosín‐Tomás, Manuel Lozano, Amaia Irizar, Amber Burt, Iraia García‐Santisteban, Diego Garrido-Martín, Geòrgia Escaramís, Alba Hernangomez‐Laderas, Raquel Soler-Blasco, Charles E. Breeze, Bárbara P. González‐García, Loreto Santa‐Marina, , Nora Fernández‐Jiménez

The paper identifies placental DNA methylation (DNAm) as a potential mediator of genetic risk for schizophrenia, bipolar disorder, and major depressive disorder using mQTL and GWAS data.

Nature Communications · Mar 14, 2025Peer-reviewedGenetic & Genomic Medicine

Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

Todd M. Everson, Marta Vives-Usano, Emie Seyve, Andrés Cárdenas, Marina Lacasaña, Jeffrey Mark Craig, Corina Lesseur, Emily Baker, Nora Fernández‐Jiménez, Barbara Heude, Patrice Perron, Beatriz González-Alzaga, Jane L. Halliday, Maya A. Deyssenroth, Margaret Rita Karagas, , Mariona Bustamante

This study identifies placental DNA methylation changes linked to maternal smoking during pregnancy and their associations with birth outcomes using data from the PACE consortium.

Nature Communications · Aug 24, 2021Peer-reviewedGenomics

Variation in Placental microRNA Expression Associates with Familial Cardiovascular Disease

Jesse M. Tehrani, Elizabeth M. Kennedy, Fu‐Ying Tian, Todd M. Everson, Maya A. Deyssenroth, Amber Burt, Karen E. Hermetz, Ke Hao, Jia Chen, Devin C. Koestler, Carmen J. Marsit

The paper identifies microRNAs in placental tissue associated with familial cardiovascular disease using RNA sequencing and statistical modeling.

bioRxiv · Feb 1, 2021 · PreprintGenetics

Placental microRNA Expression Associates with Birthweight through Control of Adipokines: Results from Two Independent Cohorts

Elizabeth M. Kennedy, Karen E. Hermetz, Amber Burt, Todd M. Everson, Maya A. Deyssenroth, Ke Hao, Jia Chen, Margaret Rita Karagas, Dong Pei, Devin C. Koestler, Carmen J. Marsit

The paper identifies miR-532 as a microRNA associated with birthweight percentile through regulation of adipokines in two independent cohorts.

Epigenetics · Oct 4, 2020Peer-reviewedGenetics

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Nicole M. Warrington, Robin N. Beaumont, Momoko Horikoshi, Felix R. Day, Øyvind Helgeland, Charles Laurin, Jonas Bačelis, Shouneng Peng, Ke Hao, Bjarke Feenstra, Andrew R. Wood, Anubha Mahajan, Jessica Tyrrell, Neil R. Robertson, Nigel William Rayner, , Cæcilie Trier

This study identifies genetic effects on birth weight and their impact on cardio-metabolic traits, distinguishing fetal and maternal contributions.

Nature Genetics · May 1, 2019Peer-reviewedGenetics