Developmental BiologyCell Death and DiseasePeer-reviewed
PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells
Jonathan De Smedt, Elise Anne van Os, Irene Talón…·Catherine M. Verfaillie
The paper introduces a computational tool to identify key transcription factors in lineage specification and validates PU.1 as a master regulator for generating LSEC-like cells from pluripotent stem cells.