PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells
Jonathan De Smedt, Elise Anne van Os, Irene Talón, Sreya Ghosh, Burak Toprakhisar, Rodrigo Madeiro da Costa, Samantha Zaunz, Marta Aguirre Vázquez, Ruben Boon, Pieter Baatsen, Ayla Smout, Stefaan Verhulst, Leo A. van Grunsven, Catherine M. Verfaillie
The paper introduces a computational tool to identify key transcription factors in lineage specification and validates PU.1 as a master regulator for generating LSEC-like cells from pluripotent stem cells.
Cell Death and Disease · Jan 14, 2021Peer-reviewedDevelopmental Biology