Author

Graham F. Brady

University of MichiganORCID 0000-0002-8376-5871Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Research Focus:genome assembly· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Kapil K. UpadhyayiD· 2 shared Alexey I. NesvizhskiiiD· 1 shared Aren Shah· 1 shared Chinmay RautiD· 1 shared Elizabeth K. SpeliotesiD· 1 shared Lishi Yin· 1 shared Venkatesha BasruriD· 1 shared Xiaomeng Du· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPhysiology

Kapil K. UpadhyayORCID

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2 papers

Recent·Most cited

The inner nuclear membrane protein SUN1 regulates cullin-3 neddylation to maintain insulin signaling

Kapil K. Upadhyay, Yunshu Yang, Aren Shah, Venkatesha Basrur, Alexey I. Nesvizhskii, Graham F. Brady

This study shows that the SUN1 H118Y variant impairs CUL3 neddylation, leading to insulin resistance, and that inhibiting neddylation can restore insulin signaling.

bioRxiv · Apr 20, 2026 · PreprintPhysiology

LMNA R644C associates with hepatic steatosis in a large cohort and increases cellular lipid droplet accumulation in vitro

Kapil K. Upadhyay, Yanhua Chen, Xiaomeng Du, Lishi Yin, Chinmay Raut, Elizabeth K. Speliotes, Graham F. Brady

Gastro Hep Advances · Jan 1, 2025Peer-reviewedGenetic & Genomic Medicine