Venkatesha Basrur

Endothelial Cell Secretome Alterations Induced by Inflammatory Stress

This study identifies conventionally and unconventionally secreted proteins from HUVECs under inflammatory stress, revealing novel UCPS cargo and their functional roles.

The inner nuclear membrane protein SUN1 regulates cullin-3 neddylation to maintain insulin signaling

This study shows that the SUN1 H118Y variant impairs CUL3 neddylation, leading to insulin resistance, and that inhibiting neddylation can restore insulin signaling.

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy

This study shows TRAF6 regulates glucose homeostasis via mitophagy in islets, with both Parkin-dependent and -independent pathways involved.

HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

This study shows HUWE1 enhances mTORC1 activity by promoting Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis via CAD activation.

Ketone body mediated histone β-hydroxybutyrylation is reno-protective

This study shows that ketone body-mediated histone β-hydroxybutyrylation in the kidney regulates chromatin structure to promote energy metabolism and suppress immune responses, offering renoprotection.

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

This study identifies LONP1's role in mitochondrial protein folding and shows its impact on beta cell survival and hyperglycemia in type 2 diabetes.

PAI-1 Interaction with Sortilin Related Receptor-1 is Required for Lung Fibrosis

The paper identifies SorlA as a novel PAI-1 interactor required for lung fibrosis, showing SorlA deficiency protects against fibrosis in mice and SorlA is upregulated in human IPF lung tissue.

Deep learning to decode sites of RNA translation in normal and cancerous tissues

This paper introduces RiboTIE, a transformer model for mapping RNA translation, showing high precision and sensitivity in normal and cancerous tissues.

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties

This study shows that endogenous retrovirus-like proteins RTL8 and PEG10 regulate UBQLN2's recruitment to stress granules and alter their functional properties.

PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia

This study identifies PAF1 and FACT as essential for enhancer activity in MLL-AF4-driven leukemia by maintaining histone acetylation and enhancer-promoter interactions.

RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control

This study identifies RTL8 as a novel UBQLN2 interactor that promotes its nuclear translocation and subnuclear localization in protein quality control.

Near-cognate initiation generates FMRpolyG from CGG repeats in Fragile X associated Tremor Ataxia Syndrome

The paper identifies and quantifies FMRpolyG, a toxic RAN translation product from FMR1 CGG repeats, using mass spectrometry in FXTAS patient samples and cell models.