Author

George Powell

Imperial College LondonPrimary ORCID profile (0000-0002-8378-0043 · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

George PowelliD3 papers · University of Oxford

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:variant effect prediction· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:GWAS summary statistics· 1 Assay:protein structure· 1

Frequent Co-Authors

James S. WareiD· 3 shared Adam S. HelmsiD· 2 shared Aaron RenbergiD· 1 shared Adelaide TovariD· 1 shared Aditya SinghiD· 1 shared Alessia Argiro· 1 shared Alexandre PereiraiD· 1 shared ANJALI TIKU OWENSiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

James S. WareORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mapping and rewiring the MYBPC3 promoter for rescue of haploinsufficiency driven hypertrophic cardiomyopathy

Aaron Renberg, Savannah Coppersmith, Owen L. Merritt, Yao-Chang Tsan, Esraa Ismail, Jennasea Licata, Maya U. Sheth, Revant Gupta, Anshul Bharat Kundaje, Sabrina Friedline, Hayden C. Helms, Elizabeth D. Hughes, Zachary Thomas Freeman, George Powell, James S. Ware, , Adam S. Helms

The paper maps and redesigns the MYBPC3 promoter to enhance expression and treat haploinsufficient hypertrophic cardiomyopathy.

bioRxiv · Sep 22, 2026 · PreprintMolecular Biology

Spatial genomics of the cardiac sarcomere

Christian Cadisch, Victoria Nicole Parikh, Megan E. Grove, Aditya Singh, Dominic James Abrams, Neal K. Lakdawala, Carolyn Yung Ho, Erin Miller, Thomas D. Ryan, J. Rossano, Kimberly Y. Lin, Anna Axelsson Raja, Henning Bundgaard, Michelle Michels, Peter-Paul M. Zwetsloot, , Euan Angus Ashley

The paper integrates genomic and structural data to identify variant intolerance regions in cardiac sarcomere genes and links them to disease mechanisms in hypertrophic cardiomyopathy.

bioRxiv · Oct 7, 2025 · PreprintGenomics

Variant annotation across homologous proteins (Paralogue Annotation) identifies disease-causing missense variants with high precision, and is widely applicable across protein families

Nicholas Li, Xiaolei Zhang, Erica Mazaika, Pantazis I. Theotokis, Mikyung Jang, Mian Ahmad, George Powell, Henrike Heyne, Dennis Lal, Paul J.R. Barton, Roddy Walsh, Nicola Whiffin, James S. Ware

This paper introduces Paralogue Annotation, a method using homologous protein variants to predict disease-causing missense variants with high precision.

bioRxiv · Aug 7, 2023 · PreprintBioinformatics