Author

Yao Ouyang

Howard Hughes Medical InstituteORCID 0000-0002-8379-5843Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Organism:bacteria (other)· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:machine learning (classical)· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Wilfred A. van der DonkiD· 2 shared Dinh Thanh NguyeniD· 1 shared Diwakar ShuklaiD· 1 shared Hassan NadeemiD· 1 shared Lingyang ZhuiD· 1 shared Yue YuiD· 1 shared Yuki GotoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

Wilfred A. van der DonkORCID

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2 papers

Recent·Most cited

BiochemistryACS Chemical BiologyPeer-reviewedOct 30, 2026

Mapping the sequence preference of the generalist class II lanthipeptide synthetase ProcM by mRNA display

Yao Ouyang, Hassan Nadeem, Yuki Goto…·Wilfred A. van der Donk

This study maps the sequence preferences of the generalist class II lanthipeptide synthetase ProcM using mRNA display and machine learning, revealing moderate predictive accuracy compared to specialized enzymes.

DOI 10.1021/acschembio.6c00753

proteomicsmachine learning (classical)

𝕏 PostBluesky

BiochemistryJournal of the American Chemical SocietyPeer-reviewedJan 19, 2026

Oxidative Peptide Backbone Cleavage by a HEXXH Enzyme During RiPP Biosynthesis

Yao Ouyang, Yue Yu, Lingyang Zhu…·Wilfred A. van der Donk

This study identifies two HEXXH enzymes that catalyze oxidative backbone cleavage in RiPP biosynthesis by recognizing specific peptide motifs.

8 citationstop 1%

bacteria (other)proteomics

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