Author

Yuki Goto

Kyoto UniversityORCID 0000-0003-4317-0790Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

Wilfred A. van der DonkiD· 2 shared Alexander A. VinogradoviD· 1 shared Dinh Thanh NguyeniD· 1 shared Diwakar ShuklaiD· 1 shared Douglas A. MitchelliD· 1 shared Hassan NadeemiD· 1 shared Hiroaki SugaiD· 1 shared Josseline S. Ramos‐FigueroaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Wilfred A. van der DonkORCID

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2 papers

Recent·Most cited

BiochemistryACS Chemical BiologyPeer-reviewedOct 30, 2026

Mapping the sequence preference of the generalist class II lanthipeptide synthetase ProcM by mRNA display

Yao Ouyang, Hassan Nadeem, Yuki Goto…·Wilfred A. van der Donk

This study maps the sequence preferences of the generalist class II lanthipeptide synthetase ProcM using mRNA display and machine learning, revealing moderate predictive accuracy compared to specialized enzymes.

DOI 10.1021/acschembio.6c00753

proteomicsmachine learning (classical)

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BiochemistryJournal of the American Chemical SocietyPeer-reviewedOct 9, 2025

Aminoacyl-tRNA specificity of a ligase catalyzing non-ribosomal peptide extension

Dinh Thanh Nguyen, Josseline S. Ramos‐Figueroa, Alexander A. Vinogradov…·Douglas A. Mitchell

This study investigates the substrate specificity of the PEARL BhaBCAla, showing it can use non-cognate amino acids and tRNAs for peptide extension, with efficiency depending on both amino acid and tRNA features.

5 citations

protein sequenceexperimental assay

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