Marina Ruiz‐Romero

The paper expands the ENCODE Registry of candidate cis-regulatory elements (cCREs) to include 2.35 million human and 927 thousand mouse cCREs, revealing novel regulatory functions and identifying KLF1 as a causal gene for red blood cell traits.

The paper identifies a conserved transcriptional program across metazoan lineages that drives cell differentiation, independent of lineage-specific factors.

The paper tracks transcriptomic and epigenomic changes during human pre-B cell to macrophage transdifferentiation, finding coordinated chromatin state transitions and gene activation patterns.

The paper identifies bsAS, an antisense lncRNA, as a regulator of bs/DSRF isoform expression, essential for cell fate determination in Drosophila development.