Amaya Abad

Uncovering functional lncRNAs by scRNA-seq with ELATUS

The paper introduces ELATUS, a computational framework for detecting functional lncRNAs from scRNA-seq data, showing improved detection and biological relevance compared to traditional methods.

A transcriptional program shared across lineages underlies cell differentiation during metazoan development

The paper identifies a conserved transcriptional program across metazoan lineages that drives cell differentiation, independent of lineage-specific factors.

Alu-mediated weak CEBPA binding and slow B cell transdifferentiation in human

The paper identifies weak CEBPA binding in humans as a cause of slower B cell transdifferentiation compared to mice, linked to Alu repeat expansions.

Dynamics of gene expression and chromatin marking during cell state transition

The paper tracks transcriptomic and epigenomic changes during human pre-B cell to macrophage transdifferentiation, finding coordinated chromatin state transitions and gene activation patterns.

bsAS, an antisense long non-coding RNA, controls cell fate through regulation of blistered/DSRF isoform expression

The paper identifies bsAS, an antisense lncRNA, as a regulator of bs/DSRF isoform expression, essential for cell fate determination in Drosophila development.

High-throughput annotation of full-length long noncoding RNAs with Capture Long-Read Sequencing

The paper introduces RNA Capture Long Seq (CLS) to annotate full-length lncRNAs with high throughput and accuracy, doubling annotated complexity compared to short-read methods.