Sílvia Pérez-Lluch

The paper identifies a conserved transcriptional program across metazoan lineages that drives cell differentiation, independent of lineage-specific factors.

The paper identifies weak CEBPA binding in humans as a cause of slower B cell transdifferentiation compared to mice, linked to Alu repeat expansions.

The paper shows that tissue-specific enhancers are mostly intronic and regulate genes involved in tissue-specific functions, while housekeeping genes are controlled by intergenic enhancers.

The paper introduces a paired-guide RNA CRISPR-Cas9 system to identify protein-coding and lncRNA genes involved in human B-cell to macrophage transdifferentiation, identifying 26 potential novel genes.

The paper tracks transcriptomic and epigenomic changes during human pre-B cell to macrophage transdifferentiation, finding coordinated chromatin state transitions and gene activation patterns.

The paper identifies bsAS, an antisense lncRNA, as a regulator of bs/DSRF isoform expression, essential for cell fate determination in Drosophila development.

The paper introduces RNA Capture Long Seq (CLS) to annotate full-length lncRNAs with high throughput and accuracy, doubling annotated complexity compared to short-read methods.