Emilio Palumbo

The paper uses long-read RNA-seq from diverse human populations to reveal ancestry bias in gene annotations and shows improved transcript discovery with personal genome assemblies.

The paper expands the lncRNA catalog using capture long-read RNA sequencing, significantly increasing the number of annotated transcripts in human and mouse genomes.

The paper introduces CapTrap-seq, a method for full-length RNA transcript sequencing, and shows it produces highly accurate transcript models in human tissues.

The paper identifies shared transcriptome alterations across neurodegenerative and psychiatric disorders using post-mortem brain samples.

The paper tracks transcriptomic and epigenomic changes during human pre-B cell to macrophage transdifferentiation, finding coordinated chromatin state transitions and gene activation patterns.

The paper identifies bsAS, an antisense lncRNA, as a regulator of bs/DSRF isoform expression, essential for cell fate determination in Drosophila development.

This study compares the epigenomes of neutrophils and monocytes to identify regulatory elements and chromatin states, revealing differences in enhancer activity and DNA methylation.

LncATLAS provides a database of lncRNA subcellular localization in human cells using RNA-seq data, offering tools to query and compare localization across cell types and organelles.

The paper identifies 15 high-confidence cancer driver lncRNAs across 1112 tumour genomes using a mutational pattern analysis approach.

ChimPipe identifies chimeric transcripts from RNA-seq data with high accuracy, detecting both fusion genes and transcription-induced chimeras with better sensitivity and precision than existing tools.

CRISPETa is a scalable bioinformatic pipeline for designing paired CRISPR guide RNAs for genomic deletion, achieving ≥50% deletion efficiency in tested cases.